Morphofunctional study on inputs of the environmental information
 three dimensional interacition and life cycle
 of a new system for reproductive regulation.

Japan Society for the Promotion of Science

Grants-in-Aid for Scientific Research

Hitoshi Ozawa

Grant-in-Aid for Scientific Research (C)

https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460323

We investigated about the kisspeptin neurons
 which is known as the center of reproductive regulation and integrate the several information in the brain to relay to the HPG axis. Actually
 we clearly investigated 1) the subcellular localization of kisspepin
 NKB
 and dynorphin in the KNDy neuronos
 which are coexpressed kisspepin
 NKB
 and dynorphin in the arcute nucleus by immunoelectron microscopy
 2) the interrelationship between the change of kisspetpin neurons and athe change of reproductive function with aging
 3) the mapping of kisspeptin receptor expression in the rat brain
 and 4) the change of expression of kisspepin of certain kind of model animals suc as PCOS an/or hypothyroidism.